I think it has a lot to do with line stretch and line memory as well. Mono stretches and fluoro does not, so if you crank the reel on a tight line (like when it is being pulled away from you by the fish), you are wrapping very tight coils of line around your spool. The stretch of monofiliment line naturally wants to expand so it will come flying off of your reel when you go to make your next cast. I think the lack of stretch of fluorocarbon line causes it to remember the coils as it is forced onto the spool if it's packed on too tightly. Either way, I always reel my line in with "tension, but not too much pressure". I also use a swivel with any type of inline-spinner, and walk off and re-reel 50yrds of line in my driveway before I head out on a fishing trip.
Has anyone had any success with those "line conditioners" you can spray on your line?
-House